Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors |
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| Authors: | Lim Hyun-Suk Park Jeong-Ju Ko Kwangseok Lee Mee-Hyun Chung Sung-Kee |
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| Affiliation: | Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja-Dong, Nam-gu, Pohang 790-784, South Korea. |
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| Abstract: | Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors. |
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