Attenuation of fibrosis in vitro and in vivo with SPARC siRNA |
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| Authors: | Jiu-Cun Wang Syeling Lai Xinjian Guo Xuefeng Zhang Benoit de Crombrugghe Sonali Sonnylal Frank C Arnett Xiaodong Zhou |
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| Affiliation: | (1) State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, 200433, PR China;(2) Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Medical School at Houston, 6431 Fannin St, Houston, Texas 77030, USA;(3) Department of Pathology, Baylor College of Medicine, One Baylor plaza, Houston, Texas 77030, USA;(4) Department of Molecular Genetics, MD. Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Houston, Texas 77030, USA |
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| Abstract: | Introduction SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases. The purpose of this study was to examine whether inhibition of SPARC can regulate collagen expression in vitro and in vivo, and subsequently attenuate fibrotic stimulation by bleomycin in mouse skin and lungs. |
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