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Potent and selective xanthine-based inhibitors of phosphodiesterase 5 |
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| Authors: | Arnold Nichola J Arnold Ruth Beer David Bhalay Gurdip Collingwood Stephen P Craig Sarah Devereux Nicholas Dodds Mark Dunstan Andrew R Fairhurst Robin A Farr David Fullerton Joseph D Glen Angela Gomez Sylvie Haberthuer Sandra Hatto Julia D I Howes Colin Jones Darryl Keller Thomas H Leuenberger Beate Moser Heinz E Muller Irene Naef Reto Nicklin Paul A Sandham David A Turner Katharine L Tweed Morris F Watson Simon J Zurini Mauro |
| Affiliation: | Novartis Institutes of Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK. |
| Abstract: | Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent inhibitors of PDE5, with good levels of selectivity against other PDE isoforms, including PDE6. Studies in the dog indicate excellent oral bioavailability for compound 21. |
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