Linkage of chloroquine resistance in Plasmodium berghei to infection of immature erythrocytes of mice. |
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Authors: | C D Fitch |
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Affiliation: | Departments of Internal Medicine and Biochemistry Saint Louis University School of Medicine, St. Louis, Mo. 63104, USA |
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Abstract: | Studies of infective potency were done to determine why chloroquine-resistant is an obligate parasite of immature erythrocytes. Infective potency was estimated from the length of time required for mice to develop parasitemia of 2% (delay in parasitemia). The delay in parasitemia was an inverse linear function of the logarithm of the number of parasites inoculated. A single regression line fitted the data both for susceptible and for resistant parasites, indicating identical infective potencies which, in turn, indicates that chloroquine-resistant selects and preferentially infects immature erythrocytes whereas it rejects mature erythrocytes. |
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