亚低温治疗急性重度颅脑损伤120例临床疗效分析

摘要目的：研究亚低温治疗对于急性重度颅脑损伤临床疗效。方法：将226例急性重度颅脑损伤患者随机分为治疗组与对照组。治疗组120例，对照组106例。对照组采用颅脑损伤常规治疗。治疗组在对照组基础上加用亚低温治疗。观察两组患者治疗前后颅内压、血糖变化。对比两组患者治疗前后GCS评分、GOS评分及不良反应发生率。结果：治疗组于治疗1d、3d及7d时颅内压与血糖值均明显低于对照组（P〈0．01）。治疗3个月时治疗组平均GCS评分明显高于对照组（P〈0．01）；治疗组恢复良好比例高于对照组（P〈O．05），而死亡率低于对照组（P〈0．05）。两组患者治疗不良反应发生率无明显区别（P〉0．05）。结论：采用亚低温疗法有助于辅助降低急性重度颅脑损伤患者颅内压及血糖，保护脑细胞，改善患者预后，降低死亡率。

Clinical Effect Analysis of the Moderate Hypothcrmia in the Treatment of 120 Cases with Severe Craniocerebral Injury

Objective： To explore the clinical effect of the moderate hypothcrmia in the treatment of 120 cases with severe craniocerebral injury. Methods： Randomly divided 226 cases with severe craniocerebral injury into the treatment group and control group. The treatment had 120 cases when the control group had 106 cases. The control group was taken the normal treatment of severe craniocerebral injury. The treatment group was added moderate hypothcrrnia on the basis of the control group＇s treatment. Observed intracranial pressure and blood sugar of the two groups＇ patients before and after the treatment. Compared the GCS scores before and after the treatment, GOS scores and adverse effects rate between the two groups. Results： The intracranial pressure and blood sugar in the treatment group at the 1st d, 3rd d and 7th d were all obviously lower than those data in the control group （P〈0.01）. After 3 months of treatment, the GCS score of the treatment group was obviously higher than the control group （P〈0.01）; The good recovery ratio of the treatment group was higher than that in the control group （P〈0.05）, and the mortality in the treatment group was lower than the control group （P〈0.05）. There was no difference of adverse effects rate between the two group （P〉0.05）. Conclusion： Moderate hypothcrmia therapy has the advantages of reducing the intracranial pressure and blood sugar of the patients with severe craniocerebral injury, protecting the brain cell and improving the patients＇ prognosis.