Synthesis of vitamin D5: its biological activity relative to vitamins D3 and D2. |
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| Authors: | J L Napoli M A Fivizzani H K Schnoes H F DeLuca |
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| Institution: | Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706 U.S.A. |
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| Abstract: | The chemical synthesis, spectral characterization, and biological activity of vitamin D5 in vitamin D-deficient rats is reported. Vitamin D5 is about 180-fold less active than vitamin D3 in calcification of rachitic cartilage and about 100- to 200-fold less active in induction of bone-calcium mobilization. In stimulation of intestinal-calcium transport, vitamin D5 is about 80-fold less active than vitamin D3. Vitamins D2 and D3 appear to be equiactive in all three responses when low doses are administered. |
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| Keywords: | To whom all correspondence should be addressed |
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