Human cystatin, a new protein inhibitor of cysteine proteinases |
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Authors: | J Brzin T Popovic V Turk U Borchart W Machleidt |
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Institution: | Department of Biochemistry, J. Stefan Institute Jamova 39, 61000 Ljubljana, Yugoslavia;Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München Goethestraße 33, 8000 München 2, FRG |
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Abstract: | A new low-molecular weight protein inhibitor of cysteine proteinases, human cystatin, was isolated from sera of patients with autoimmune diseases. It inhibits papain, human cathepsin H and cathepsin B. According to its partially determined amino-acid sequence, human cystatin is highly homologous to egg white cystatin, but only distantly related to stefin, the cytosolic protein inhibitor of cysteine proteinases isolated from human polymorphonuclear granulocytes. Very probably human cystatin is identical with human gamma-trace, a microprotein of known sequence but hitherto unknown function. |
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