Evidence for an additional cattle DQB locus |
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Authors: | A Gelhaus Birgit Förster Rolf D Horstmann |
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Institution: | (1) Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany e-mail: gelhaus@bni.uni-hamburg.de, Tel.: +49-40-42818534, Fax: +49-40-42818512, DE |
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Abstract: | Studying the genetic polymorphism of the major histocompatibility complex class II genes in cattle, we identified a sequence
(KUH1) which resembles those encoding class II β chains. The gene was shown to be transcribed in peripheral blood leukocytes. Sequence
comparisons, Southern blot, and phylogenetic analyses indicate that (1) KUH1 represents a distinct DQB locus, which we propose to designate BoLA-DQB5, (2) DQB5 constitutes an ancient DQB locus which diverged from a common ancestor gene prior to the duplication resulting in DQB1 and DQB2, (3) DQB5 is associated with haplotypes which contain DQA5 and a duplicated DQ region.
Received: 26 January 1999 / Revised: 20 April 1999 |
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Keywords: | MHC Cattle DQB BoLA-DQB5 Haplotype |
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