表观遗传学修饰在血液肿瘤中的研究进展

血液肿瘤作为一类常见恶性肿瘤疾病主要包括各类白血病、多发性骨髓瘤以及恶性淋巴瘤.随着现代社会高速发展,人群发病率呈逐年升高趋势,且发病年龄逐渐低龄化,发病原因与环境因素以及遗传因素密不可分.近年来研究发现,表观遗传学修饰在血液肿瘤发生发展的过程中扮演了重要角色,一些相关修饰基因作为血液肿瘤的治疗靶点在临床应用上取得了重要进展.针对近年来表观遗传学修饰在血液肿瘤中的研究新进展,本文将系统综述DNA甲基化、组蛋白修饰、非编码RNA及RNA修饰等在血液肿瘤发病机制方面的研究进展.

The progress of epigenetic modification in hematological malignancies research

As a common type of malignant tumor diseases, hematological malignancies mainly include various types of leukemia, multiple myeloma and malignant lymphoma. With the rapid development of modern society, the incidence rate of hematological malignancies is increasing year by year, and the age of disease onset gradually tend to a younger age. The pathogenesis of hematological malignancies is inseparable from environmental factors and genetic factors. Recent studies have found that epigenetic modification plays an important role in the development of hematological tumors and some epigenetic related genes have made important progress in clinical application as therapeutic targets for hematological tumors. In view of the advances progress of the research that focus on the role of epigenetic modification in the pathogenesis of hematological malignancies, this paper will systematically review the research progress of DNA methylation, histone modification, non-coding RNA and RNA modification in the pathogenesis of hematological tumors.