| 细胞色素P450酶的结构、功能与应用研究进展 |
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| 引用本文： | 宋展,高鑫,吴冕,路福平,秦慧民. 细胞色素P450酶的结构、功能与应用研究进展[J]. 微生物学通报, 2020, 47(7): 2245-2254 |
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| 作者姓名： | 宋展 高鑫 吴冕 路福平 秦慧民 |
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| 作者单位： | 1 工业发酵微生物教育部重点实验室 天津 300457;2 天津科技大学生物工程学院 天津 300457;1 工业发酵微生物教育部重点实验室 天津 300457;2 天津科技大学生物工程学院 天津 300457;3 工业酶国家工程实验室 天津 300457 |
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| 基金项目： | 国家自然科学基金(31771911) |
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| 摘 要： | 细胞色素P450 (cytochrome P450,CYP)酶是广泛存在于微生物、动植物及人体中与膜结合的血红蛋白类酶,具有氧化、环氧化、羟化、去甲基化等多种生物催化活性。CYP酶在药物、类固醇、脂溶性维生素和许多其他类型化学物质的代谢中具有重要作用,其在异源物质的解毒、药物相互作用和内分泌功能等领域的研究是热点问题。本综述对CYP的结构、功能、临床应用与开发前景进行了概述,并对其最新的研究现状和发展前景进行探讨。
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| 关 键 词： | 细胞色素P450，还原酶，结构，功能，遗传多态性 |
Structure, function, and application of cytochrome P450 enzymes |
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| SONG Zhan,GAO Xin,WU Mian,LU Fu-Ping,QIN Hui-Min. Structure, function, and application of cytochrome P450 enzymes[J]. Microbiology China, 2020, 47(7): 2245-2254 |
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| Authors: | SONG Zhan GAO Xin WU Mian LU Fu-Ping QIN Hui-Min |
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| Affiliation: | 1 Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, Tianjin 300457, China;2 College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China;1 Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, Tianjin 300457, China;2 College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China;3 National Engineering Laboratory for Industrial Enzymes, Tianjin 300457, China |
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| Abstract: | Cytochrome P450 (CYP), membrane-bound hemoglobin enzymes, are widely present in microorganisms, animals, plants, and human. CYPs have a variety of biocatalytic activities such as oxidation, epoxidation hydroxylation, demethylation et al. Therefore, they play a key role in detoxification of biotin, cell metabolism and maintaining homeostasis. More importantly, the catalytic activity of CYPs is a hot issue in the fields of drug interaction and endocrine function. Furthermore, they are also widely utilized in the metabolism of drugs, carcinogens, steroids, fat-soluble vitamins and many other types of chemicals. This review provides a comprehensive overview of the structure, function, clinical application, and development prospects of CYPs. Besides, we aim to discuss the latest research and development prospects of CYPs. |
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| Keywords: | Cytochrome P450 Reductase Structure Function Genetic polymorphism |
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