Aldosterone induced changes in protein synthesis in rat intestine

Adrenalectomy decreases the incorporation of [¹⁴C]-leucine into the acid insoluble fraction of both the small and large intestinal mucosa of adrenalectomised rats. Aldosterone injection (1 μg and 10 μg/100 g body weight) restores incorporation values to normal. Deoxycorticosterone and corticosterone do not show such an effect. In the case of large intestine there is a greater stimulation of incorporation into cytosol than into other sub-cellular fractions. No effect of hormones could be demonstrated on protein synthesis by bladder.