Steroid metabolism in testicular tissue of genetic mutant mice |
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| Affiliation: | 1. Facultad de Psicología, Universidad Nacional de Educación a Distancia, 28040 Madrid, Spain;2. Departamento de Psicobiología, Facultad de Psicología, Universidad Nacional de educación a Distancia, 28040 Madrid, Spain;3. Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas, 28029 Madrid, Spain;4. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Granada, 18016 Granada, Spain;5. Departamento de Psicología, Universidade da Coruña, 15071 A Coruña, Spain;6. Unidad de Identidad de Género, Departamento de Psiquiatría, Hospital Clínic, 08036 Barcelona, Spain;7. Departamento de Endocrinología, Hospital Clínic, 08036 Barcelona, Spain |
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| Abstract: | The conversion of testosterone and progesterone to other products was studied in testes of normal BALB/C mice, testieular, feminized (Tfm o+) and testicular feminized mice carrying the protective (ohv) gene. The formation of testosterone from progesterone was 11 ± 1.3% in normal mice, 2.20 ± 0.8% in (Tfm ohv) and 0.8 ± 0.2% in (Tfm o+ mice. With androstenedione as substrate, both (Tfm o+) and (Tfm ohv) synthesized testosterone equally well. Testicular progesterone metabolism was also compared between normal and sex reversed (sxr) mice. The data suggested that the 17β hydroxysteroid dehydrogenase was more active in normal mice whereas the testes from the sex reversed (Tfm ohv) gave higher conversions to androstenedione. Some conversion to dihydrotestosterone and androstanediol was found in all the testicular incubations. |
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