Serum ribonuclease levels in patients with cystic fibrosis |
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| Affiliation: | 1. Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000CA Rotterdam, the Netherlands;2. Department of Surgery, Erasmus MC Transplant Institute, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000CA Rotterdam, the Netherlands;3. Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC-Sophia Children''s Hospital, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000CA Rotterdam, the Netherlands;1. CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA 02421, USA;2. University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;3. Rosalind Franklin University Medical School, Chicago, IL 60064, USA;4. University of Washington, Seattle, WA 98195-9300, USA;5. Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA;6. Cystic Fibrosis Foundation, Bethesda, MD 20814, USA |
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| Abstract: | The levels of serum pancreatic-type ribonuclease (RNase) activity in normal individuals and in individuals homozygous and heterozygous for the cystic fibrosis (CF) gene have been studied. In 21 CF patients, ages 3–24 years, RNase levels of 459 ± 95 units/ml did not differ significantly from the RNase levels of 467 ± 105 units/ml in 17 normal individuals of the same age group nor from those of 490 ± 52 units/ml in 5 individuals heterozygous for the CF gene. |
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