Impaired renal prostaglandin E2 biosynthesis in human hypertensive states |
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| Affiliation: | 1. Department of Medicine, Medical College of Ohio, Toledo, Ohio, USA;2. Cleveland Clinic, Cleveland, Ohio, USA;1. Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan;2. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;3. Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan;4. AbGenomics BV, Taiwan Branch, Neihu, Taipei, Taiwan;5. Department of Forensic Medicine and Pathology, National Taiwan University Hospital, Taipei, Taiwan;6. Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan;1. Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;2. Department of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba, Japan;3. Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA;4. Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women''s College of Liberal Arts, Kyotanabe, Kyoto, Japan;1. Department of Internal Medicine, National Taiwan University Hospital, Taipei 100225, Taiwan;2. Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei 100225, Taiwan;3. Institute of Biomedical Sciences, Academia Sinica, Taipei 115201, Taiwan;4. Graduate Institute of Molecular Medicine, National Taiwan University, Taipei 100225, Taiwan;5. Department of Pathology, National Taiwan University, Taipei, Taiwan;6. Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan;7. Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan;8. Graduate Institute of Clinical Medicine, National Taiwan University, Taipei 100225, Taiwan;9. Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, USA |
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| Abstract: | Urinary Prostaglandin E2 (PGE2), a known indicator of renal production, was measured by specific radioimmunoassay in 111 normal volunteers, 85 patients with essential hypertension, 6 with renovascular hypertension, and 23 patients with primary aldosteronism. Women excreted less PGE2 than men in both normotensive and hypertensive groups. When compared to normals, essential hypertensives demonstrated significantly lower PGE2 levels, with one third excreting less than 100 ng/24 hr, values usually seen only in subjects receiving the prostaglandin synthetase inhibitor, indomethacin. Normal PGE2 was seen in patients with renovascular hypertension, and levels were uninfluenced by treatment with the converting enzyme inhibitor SQ14225, despite normalization of blood pressure and increased plasma renin activity. Normal PGE2 was also encountered in primary aldosteronism. These data indicate that impaired renal PGE2 biosynthesis is specific for human essential hypertension, and is not secondary to the elevated blood pressure. Although PGE2 excretion tends to be lower in low-renin hypertension, a constant relationship between PGE2 and renin is not always apparent. |
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