Studies on enantioselective hydrolysis of the acetic ester of a secondary alcohol with Arthrobacter lipase |
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Authors: | Satoshi Mitsuda Shigeyasu Nabeshima Hideo Hirohara |
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Affiliation: | (1) Takarazuka Research Center, Sumitomo Chemical Co. Ltd., 4-2-1 Takatsukasa, 665 Takarazuka, Hyogo, Japan |
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Abstract: | Summary Characteristics of the enantioselective hydrolysis of the acetic ester of 4-hydroxy-3-methyl-2-(2-propynyl)-2-cyclopentenone (HMPC) by Arthrobacter lipase were investigated in a water/oil biphasic reaction mixture. Kinetic studies revealed that the strict enantioselectivity was entirely due to a difference in the catalytic constants for the enantiomeric substrates and that (S)-HMPC acetate acted as a competitive inhibitor. The comparison of enantioselectivity for the acetates of HMPC analogues indicated that hydrophobic substituents in the HMPC molecule were essential for the strict enantioselectivity.Biological preparation of an optically active alcohol. Part II |
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