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Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells |
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| Authors: | Zeina Saikali Hemani Setya Gurmit Singh Sujata Persad |
| Institution: | (1) Department of Research, Juravinski Cancer Centre, Hamilton, Canada;(2) Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada;(3) Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada;(4) Presently at: Department of Pediatrics, University of Alberta, Edmonton, Canada |
| Abstract: | BackgroundProstate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. |
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