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Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells
Authors:Zeina Saikali  Hemani Setya  Gurmit Singh  Sujata Persad
Institution:(1) Department of Research, Juravinski Cancer Centre, Hamilton, Canada;(2) Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada;(3) Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada;(4) Presently at: Department of Pediatrics, University of Alberta, Edmonton, Canada
Abstract:

Background  

Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present.
Keywords:
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