Investigations of TB vaccine-induced mucosal protection in mice |
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Institution: | 1. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea;2. Department of Internal Medicine, Konyang University Hospital, Daejeon, Republic of Korea;3. Department of Occupational Health Care, Konyang University Hospital, Daejeon, Republic of Korea |
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Abstract: | A better understanding of mucosal immunity is required to develop more protective vaccines against Mycobacterium tuberculosis. We developed a murine aerosol challenge model to investigate responses capable of protecting against mucosal infection. Mice received vaccinations intranasally with CpG-adjuvanted antigen 85B (Ag85B/CpG) and/or Bacillus Calmette–Guerin (BCG). Protection against aerosol challenge with a recombinant GFP-expressing BCG was assessed. Mucosal prime/boost vaccinations with Ag85B/CpG and BCG were protective, but did not prevent lung infection indicating more efficacious mucosal vaccines are needed. Our novel finding that protection correlated with increased airway dendritic cells early post-challenge could help guide the development of enhanced mucosal vaccines. |
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Keywords: | BCG Vaccination Mucosal specific immunity |
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