Vitamin D supplementation promotes macrophages' anti-mycobacterial activity in type 2 diabetes mellitus patients with low vitamin D receptor expression |
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| Institution: | 1. Medical Research Unit Zacatecas, Mexican Institute for Social Security, Zacatecas, Mexico;2. Medical Research Coordination SSA-Zacatecas, Zacatecas, Mexico;1. University Lille1, Laboratoire d’Electrotechnique et d’Electronique de Puissance, France;2. University Lille1, Villeneuve d’Ascq Cedex, France;3. Department of Electrical & Computer Engineering of the University of Toronto, Toronto, Canada;4. École Nationale des Arts & Métier Paris-Tech, Lille, France;1. Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamilnadu, India;2. National Physical Laboratory, New Delhi 110012, India;1. Astronomical Observatory, Belgrade 11060, Serbia;2. Observatoire de Lyon, 9 avenue Charles André, Saint-Genis Laval cedex, F-69561, CNRS, UMR 5574, France;1. Department of Clinical and Experimental Medicine, University of Firenze, Largo Brambilla 3, I-50134, Firenze, Italy;2. Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Roma, Italy;3. Department of Biomedical, Experimental and Clinical Science, University of Firenze, Viale Giovan Battista Morgagni 50, I-50134, Firenze, Italy |
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| Abstract: | The increasing number of people with type 2 diabetes (DM2) is alarming and if it is taken into account that the relative odds of developing tuberculosis in diabetic patients ranges from 2.44 to 8.33 compared with non-diabetic patients, thus in developing countries where these two diseases are encountering face to face, there is a need for prophylaxis strategies. The role of vitamin D has been widely implicated in growth control of Mycobacterium tuberculosis (Mtb) during primary infection mainly through the induction of certain antimicrobial peptides (AMPs). In this study we evaluated the vitamin D serum levels, CYP27B1-hydroxylase enzyme, vitamin D receptor (VDR) and AMPs gene expression in Healthy donors, DM2 and TB patients. Results showed that DM2 group has lower VDR and AMPs expression levels. When Monocytes Derived Macrophages (MDM) from DM2 patients with low VDR expression were supplemented with vitamin D, MDMs eliminate efficiently M. tuberculosis. This preliminary study suggests the use of vitamin D as prophylaxis for tuberculosis in high DM2 endemic countries. |
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| Keywords: | Diabetes Vitamin D Antimicrobial peptides Tuberculosis Cathelicidin Defensin |
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