Innate immune sensing of nucleic acids from pathogens |
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| Institution: | 1. Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China;2. Department of Anesthesiology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China;1. Centre for Mined Land Rehabilitation, Sustainable Minerals Institute, The University of Queensland, Queensland, Australia;2. Université de Lorraine, INRA, Laboratoire Sols et Environnement, 54000 Nancy, France;3. Chaney Environmental, Beltsville, MD, USA;4. School of BioSciences, The University of Melbourne, Australia |
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| Abstract: | The innate immune system is important as the first line of defense to sense invading pathogens. Nucleic acids represent critical pathogen signatures that trigger a host proinflammatory immune response. Much progress has been made in understanding how DNA and RNA trigger host defense countermeasures, however, several aspects of how cytosolic nucleic acids are sensed remain unclear. This special issue reviews how the host innate immune system senses nucleic acids from Brucella abortus, Mycobacterium sp and Legionella pneumophila, viral DNA, the role of STING in DNA sensing and inflammatory diseases and the mechanism of viral RNA recognition by the small interfering RNA pathway in Drosophila melanogaster. |
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| Keywords: | Innate immunity Cytosolic sensors DNA sensing RNA receptors TLRs STING |
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