The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases – Lessons learned from experimental models |
| |
| Institution: | 1. Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra 08193, Barcelona, Spain;2. Neuroscience Institute, Universitat Autònoma de Barcelona, Bellaterra 08193, Barcelona, Spain;3. Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland;1. Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, and Texas Children''s Hospital, Houston, Texas, USA;2. Dan L. Duncan Cancer Center, Baylor College of Medicine, The Methodist Hospital, and Texas Children''s Hospital, Houston, Texas, USA;3. Program for Cell Enhancement and Technologies for Immunotherapy, Center for Cancer and Immunology Research, and Sheikh Zayed Institute for Pediatric Surgical Innovation, Children''s National Health System, Washington, DC, 20010;4. Department of Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, Texas, USA;1. Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, China;2. Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada;3. Department of Oncology, Tongde Hospital of Zhejiang Province, Hangzhou, China;4. Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada;5. Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China |
| |
| Abstract: | Inflammasomes are a large family of multiprotein complexes recognizing pathogen-associated molecular pattern molecules (PAMPs) and damage-associated molecular patterns (DAMPs). This leads to caspase-1 activation, promoting the secretion of mature IL-1β, IL-18 and under certain conditions even induce pyroptosis. Inflammatory Bowel Diseases (IBD) is associated with alterations in microbiota composition, inappropriate immune responses and genetic predisposition associated to bacterial sensing and autophagy. Besides their acknowledged role in mounting microbial induced host responses, a crucial role in maintenance of intestinal homeostasis was revealed in inflammasome deficient mice. Further, abnormal activation of these functions appears to contribute to the pathology of intestinal inflammation including IBD and colitis-associated cancer. Herein, the current literature implicating the inflammasomes, microbiota and IBD is comprehensively reviewed. |
| |
| Keywords: | Inflammasomes Microbiota IBD Colitis-associated cancer Caspase-1 |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
