Strongyloides stercoralis genotypes in humans in Cambodia |
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| Institution: | 1. Swiss Tropical and Public Health Institute, Basel, Switzerland;2. University of Basel, Basel, Switzerland;3. Department for Evolutionary Biology, Max-Planck-Institute for Developmental Biology, Tuebingen, Germany;4. National Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia;5. Medical and Diagnostics Department, Swiss Tropical and Public Health Institute, Basel, Switzerland;1. National Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia;2. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland;3. University of Basel, Basel, Switzerland;4. Medical Department and Diagnostics, Swiss Tropical and Public Health Institute, Basel, Switzerland;1. Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo, Tokyo 113-8657, Japan;2. Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan;3. Food Sanitation Inspection Laboratory of Osaka Municipal Central Wholesale Market, 1-1-86 Noda, Fukushima-ku, Osaka 553-0005, Japan;4. Tokyo Metropolitan Institute of Public Health, Hyakunin-cho, Shinjuku, Tokyo 169-0073, Japan;1. Swiss Tropical and Public Health Institute, Basel, Switzerland;2. University of Basel, Basel, Switzerland;3. Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark;4. Department of Parasitology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand;5. School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia;6. National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia;7. Department of Fisheries Post-Harvest Technologies and Quality Control (DFPTQ), Fisheries Administration, Cambodia;8. Department of Medical Services and Diagnostics, Swiss Tropical and Public Health Institute, Basel, Switzerland;1. Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;2. Health and Epidemiology Geoinformatics Research (HEGER), Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand;3. Cholangiocarcinoma Screening and Care Program (CASCAP), Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;4. Data Management and Statistical Analysis Center (DAMASAC), Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand;5. Department of Biology, Faculty of Science and Technology, Sakon Nakhon Rajabhat University, Sakon Nakhon, Thailand;6. Department of Global Health, Research School of Population Health, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australian Capital Territory, Australia;7. School of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia;8. Faculty of Health Sciences, Curtin University, Bentley, Western Australia, Australia;9. Telethon Kids Institute, Nedlands, WA, Australia;10. Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand;11. WHO Collaborating Centre for Research and Control of opisthorchiasis, Tropical Disease Research Center, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand |
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| Abstract: | Little is known about the genetic variability of the soil-transmitted nematode, Strongyloides stercoralis, in humans. We sequenced portions of the small subunit rDNA (SSU), including the hyper variable regions (HVR) I and IV from S. stercoralis larvae derived from individuals living in a rural setting in Cambodia. We identified three polymorphic positions, including a previously reported one within the HVR I. HVR IV was invariable. Six different SSU alleles existed in our sample. Although different genotypes of S. stercoralis were found in the same individuals, no heterozygous larvae were found. This indicates that there is no or very little interbreeding between the different genotypes. Further studies are needed to examine if this is because sexual reproduction, which is facultative, is rare in our study area's S. stercoralis population or because what is considered to be S. stercoralis today is actually a complex of closely related species or subspecies. |
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