Valley fever: danger lurking in a dust cloud |
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| Institution: | 1. Department of Molecular Cell Biology, University of California, Merced, CA 95343, USA;2. Health Sciences Research Institute, University of California, Merced, CA 95343, USA;3. Department of Internal Medicine, University of California San Francisco – Fresno, Fresno, CA 93703, USA;1. Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China;2. Huzhou Center for Disease Control and Prevention, Huzhou, Zhejiang 313000, China;1. School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA;1. Department of Pediatrics, Georgetown University Hospital, Washington, District of Columbia;2. Georgetown University Medical Center, Washington, District of Columbia;3. Department of Pediatrics, Division of General Pediatrics and Adolescent Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland;1. Laboratories of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu, Tokyo 183-8509, Japan;2. Laboratories of Comparative Animal Medicine, Division of Animal Life Science, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu, Tokyo 183-8509, Japan;3. Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo 060-0818, Japan;1. Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB-CSIC), 28049 Madrid, Spain;2. Departamento de Biología Molecular, Universidad Autónoma de Madrid. Centro de Biología Molecular ‘Severo Ochoa’-Consejo Superior de Investigaciones Científicas (CBMSO-CSIC), 28049 Madrid, Spain |
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| Abstract: | Coccidioides immitis and Coccidioides posadasii contribute to the development of Valley Fever. The ability of these fungal pathogens to evade the host immune system creates difficulty in recognition and treatment of this debilitating infection. In this review, we describe the current knowledge of Valley Fever and approaches to improve prevention, detection, and treatment. |
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| Keywords: | Innate immunity Adaptive immunity Fungal pathogen Lung infection |
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