The role of bone morphogenetic proteins in myeloma cell survival |
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| Affiliation: | 1. KG Jebsen Center for Myeloma Research, Department of Cancer Research and Molecular Medicine, NTNU, Faculty of Medicine, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway;2. Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, NTNU, Faculty of Medicine, Norwegian University of Science and Technology, Postbox 8905, 7491 Trondheim, Norway;1. Laboratory of Oncology, Istituto Giannina Gaslini, Via Gaslini 1, 16147 Genoa, Italy;2. CEA, Institut des Maladies Emergentes et des Therapies Innovantes (iMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, Avenue Claude Vellefaux 1, 75010 Paris, France;1. Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), C1428 Buenos Aires, Argentina;2. Departamento de Neurología, Instituto de Investigaciones Neurológicas Dr. Raúl Carrea, FLENI, C1428 Buenos Aires, Argentina;3. Laboratorio de Glicómica Funcional y Molecular, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), C1428 Buenos Aires, Argentina;4. Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428 Buenos Aires, Argentina;1. Keizo Asami Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil;2. Neuropsychiatry Department, Federal University of Pernambuco, Recife, Pernambuco, Brazil;1. IIS-Fundacion Jimenez Diaz, Madrid, Spain;2. REDINREN, Madrid, Spain;3. IDIPAZ, Madrid, Spain;4. Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden;5. Universidad Autonoma de Madrid and FRIAT/IRSIN, Madrid, Spain |
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| Abstract: | Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts. Bone morphogenetic proteins (BMPs) are present in the bone marrow and are important for several aspects of myeloma pathogenesis including growth and survival of tumor cells, bone homeostasis, and anemia. Among cancer cells, myeloma cells are particularly sensitive to growth inhibition and apoptosis induced by BMPs and therefore represent good models to study BMP receptor usage and signaling. Our review highlights and discusses the current knowledge on BMP signaling in myeloma. |
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| Keywords: | Bone morphogenetic protein BMP Multiple myeloma Apoptosis |
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