IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments |
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| Institution: | 1. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan;2. Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;3. Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan;4. Department of General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;5. Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan;6. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan;7. Department of Neurology, Cheng Hsin General Hospital, Taipei, Taiwan;8. School of Medicine, National Yang-Ming University, Taipei, Taiwan;9. Pediatric Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan;1. Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States;2. Carolina Medical Center, Multiple Sclerosis Center, Charlotte, North Carolina, 28207, United States;3. Rutgers University, Department of Statistics and Biostatistics, Piscataway, NJ 08854, United States |
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| Abstract: | Multiple sclerosis (MS), an autoimmune neurological disorder, is driven by self-reactive T helper (Th) cells. Research on the role of Th17 lymphocytes in MS pathogenesis has made significant progress in identifying various immunological as well as environmental factors that induce the differentiation and expansion of these cells, different subsets of Th17 cells with varying degrees of pathogenicity, and the role of the secreted effector cytokines. While approved therapies for MS offer significant benefit to patients, there remain unmet needs. Ongoing clinical trials aim to translate the advanced knowledge of Th17 cytokines to improved therapies. This review discusses the current status and future developments of research into the role of Th17 and related cytokines in MS pathogenesis and therapy. |
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| Keywords: | Multiple sclerosis EAE Therapy Cytokines Th17 |
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