Innate immune sensing of nucleic acids from mycobacteria |
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| Affiliation: | 1. Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Brazil;2. Pharmacology Graduate Program, Federal University of Santa Catarina, Brazil;3. Laboratory of Immunology and Infectious Diseases, Federal University of Minas Gerais, Brazil |
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| Abstract: | Endosomal and cytosolic receptors engage recognition of mycobacterial-derived nucleic acids (MyNAs). In contrast, virulent mycobacteria may utilize nucleic acid recognition pathways to escape the host immune system. This short review will summarize the mechanisms by which MyNAs are sensed and how they influence host protective responses. |
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| Keywords: | Acid nucleics Sensors Mycobacteria Tuberculosis |
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