Cytogenetic effects of diazepam in peripheral lymphocytes of self-poisoned persons. |
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| Authors: | T van Bao E Imreh A E Czeizel |
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| Institution: | Department of Human Genetics and Teratology, WHO Collaborating Centre for the Community Control of Hereditary Diseases, National Institute of Hygiene, Budapest, Hungary. |
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| Abstract: | The frequencies of chromosomal aberrations and of micronuclei were determined in lymphocyte cultures of 25 patients who attempted suicide with diazepam, 6-12 h, 72 h and 30 days after self-poisoning. These data were compared with those of healthy controls. The frequencies of numerical aberrations showed a significant increase immediately after self-poisoning. However, this effect could not be detected on the 3rd and 30th days after self-poisoning. |
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