Microwave induced synthesis and antibacterial activity of cephalosporin derivatives using solid support |
| |
| Authors: | Kidwai M Sapra P Bhushan K R Misra P Saxena R K Gupta R Singh M |
| |
| Affiliation: | Department of Chemistry, University of Delhi, Delhi, 110007, India. mkidwai@mantraonline.com |
| |
| Abstract: | Reaction of 7-amino-3-[5'-methyl-1',3',4'-thiadiazol-2'-ylthiomethyl]cephalo-sporanic acid with heterocyclic amines using basic alumina under microwave irradiation (MWI) afforded new cephalosporin analogs in shorter reaction time with improved yield as compared to conventional heating. All the synthesised compounds were tested for their in vitro antibacterial activity, using cefotaxime and cephalothin as reference drugs. All compounds showed significant in vitro antibacterial activity against E. herbicola, P. vulgaries, and Z. mobilis. |
| |
| Keywords: | cephalosporins microwave irradiation antibacterial activity solid support. |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
