Identification of the UV-responsive sequence in the human tissue plasminogen activator gene |
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| Authors: | Fujiwara J Fujii M Shimoda M Ayusawa D |
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| Affiliation: | AISIN Cosmos R&D CO., Ltd., Kazusa Incubation Center, Yana Kisarazu, Chiba, Japan. |
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| Abstract: | Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence. |
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