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Evaluation of intrauterine antibiotic treatment of clinical metritis and retained fetal membranes in dairy cows
Institution:1. The Koret School of Veterinary Medicine, Faculty of Agriculture, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel;2. The Hachakleit Veterinary Services, PO Box 3039, Caesarea Industrial Park 38900, Israel;2. Department of Dairy Science, University of Wisconsin, Madison 53706;2. Pharmacology Analytical Support Team, Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Iowa State University, Ames 50011;3. Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66502;1. Department of Large Animal Clinical Sciences, University of Florida, Gainesville, USA;2. Department of Animal Sciences, University of Florida, Gainesville, USA;1. Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;2. Department of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;3. Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran;4. Department of Biochemistry, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;5. Bostan Dairy Farm, Nazarabad, Alborz Province, Iran;1. Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis 95616;2. Department of Veterinary Preventive Medicine, Ohio State University, Columbus 43210;3. Veterinary Medicine Teaching and Research Center, 18830 Road 112, Tulare, CA 93274;1. Department of Veterinary Medical Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;2. Ishii Veterinary Support Services Inc., Shintoku-cho, Hokkaido, Japan;3. Department of Livestock Medicine, Japan Agricultural Cooperatives-Shihoro, Shihoro-cho, Hokkaido, Japan;4. Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Abstract:Retained fetal membranes (RFM) and clinical metritis (CM) are frequently diagnosed disease conditions in dairy cows and considered of major economic impact due to negative effect on reproduction and milk production. The objective of this study was to evaluate the efficacy of i.u. tetracycline for the treatment of RFM and CM in dairy cows. Affected cows were randomly assigned to two groups; treatment group animals received i.u. 5 g chlortetracycline twice weekly for 2 wks, and no treatment group.A total of 1416 cows and 804 heifers in 5 herds calved during the study period. CM was diagnosed in 18.6% (inter farm range; 15.2–23.5%) and 30% (19.4–42.3%) of cows and heifers, respectively. RFM was diagnosed in 13.1% (9.4–18.1%) and 9.2% (3.6–13.8%) of cows and heifers, respectively. Conception rates after first insemination were 38.3%, 42.5% and 18% in normal, treated and non-treated CM cows, respectively. Numbers of days open were 140.5, 136.2 and 165.5 in normal, treated and non-treated CM cows, respectively. Based on 305-d corrected milk yield, cows and heifers affected by RFM and CM produced 300–500 kg less milk compared with their normal herd mates. Cows treated for CM produced 654 kg more milk per 305-d corrected lactation compared to non-treated control cows. Treatment of RFM had no effect on reproductive performance or milk production. In conclusion, i.u. chlortetracycline treatment was proven to prevent the detrimental effect of CM on reproductive performance in heifers and cows and on milk production in cows only.
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