Monotertiarybutylhydroquinone effects on Tetrahymena pyriformis. |
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Authors: | J G Surak |
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Affiliation: | Pest. Res. Lab., Food Science Dept., Univ. of Florida, Gainesville, FL 32611, USA |
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Abstract: | The molecular toxicity of monotertiarybutylhydroquionone (TBHQ) was studied using as a model cell system. TBHQ at 26 ppm in the media inhibited cell growth by 50%. TBHQ inhibited the oxidation of 14C-acetate to 14CO2. In addition, increasing concentrations of TBHQ decreased the incorporation of 14C-acetate into lipids and protein, 14C-amino acids into protein, 3H-uridine into RNA and 3H-thymidine into DNA. The incorporation of 14C-acetate into glycogen increased with concentrations up to 20 ppm TBHQ in the media while glycogen synthesis decreased with 40 ppm TBHQ. |
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