Cellular stores of gastric histamine in the developing rat |
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| Authors: | R H?kanSON C Owman N O Sj?berg |
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| Affiliation: | 1. Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province), School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, PR China;2. Department of Chemistry, University of Zurich, Winterthurerstrasse 190, Zurich 8057, Switzerland;3. CompuTherm LLC, Middleton, WI 53562, USA;4. Department of Materials Science and Engineering, The University of Tennessee, Knoxville, TN 37996, USA;1. Key Lab of Environment and Health, School of Public Health, Xuzhou Medical University, No.209, Tongshan Road, Xuzhou 221004, Jiangsu, China;2. Yunnan Institute of Parasitic Diseases, No.6 Xiyuan Road, Simao City, Puer 665000, Yunnan, China;3. Jinan Blood Center, No.127 Jingliu Road, Jinan 250001, Shandong, , China |
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| Abstract: | With the use of a recently developed fluorescence microscopic technique for the cellular localization of histamine in combination with chemical methods for the assay of histamine and histidine decarboxylase, the appearance of histamine-storing cells in the gastric mucosa was followed in the developing rat.Histamine could be demonstrated histochemically in mast cells soon after birth. At the age of one week histamine appeared in a system of enterochromaffin-like cells. The histochemical findings agree well with the low concentration of histamine found in the stomach wall. The subsequent increase in number and fluorescence intensity of the histamine-storing cells coincided with the increase in the content of histamine and the activity of histidine decarboxylase in the stomach. The adult level of gastric histamine was reached at about 40 days after birth. |
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