A procedure for identifying homologous alternative splicing events |
| |
| Authors: | David Talavera Adam Hospital Modesto Orozco |
| |
| Affiliation: | 1.Molecular Modelling and Bioinformatics Unit, Institut de Recerca Biomèdica (IRB),Parc Científic de Barcelona (PCB),Barcelona,Spain;2.Protein Structure and Modelling Node, Instituto Nacional de Bioinfomática, Genoma Espa?a,Parc Científic de Barcelona,Barcelona,Spain;3.Departament de Bioquímica i Biologia Molecular,Universitat de Barcelona,Barcelona,Spain;4.Institució Catalana de Recerca i Estudis Avan?ats (ICREA),Barcelona,Spain;5.Computational Biology Program,Barcelona Supercomputing Center,Barcelona,Spain |
| |
| Abstract: | Background The study of the functional role of alternative splice isoforms of a gene is a very active area of research in biology. The difficulty of the experimental approach (in particular, in its high-throughput version) leaves ample room for the development of bioinformatics tools that can provide a useful first picture of the problem. Among the possible approaches, one of the simplest is to follow classical protein function annotation protocols and annotate target alternative splice events with the information available from conserved events in other species. However, the application of this protocol requires a procedure capable of recognising such events. Here we present a simple but accurate method developed for this purpose. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
