A general and efficient method for estimating continuous IBD functions for use in genome scans for QTL |
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| Authors: | Francois Besnier Örjan Carlborg |
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| Institution: | (1) Linnaeus Centre for Bioinformatics, Uppsala University, SE-75124 Uppsala, Sweden;(2) Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, SE-75005 Uppsala, Sweden |
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| Abstract: | Background Identity by descent (IBD) matrix estimation is a central component in mapping of Quantitative Trait Loci (QTL) using variance
component models. A large number of algorithms have been developed for estimation of IBD between individuals in populations
at discrete locations in the genome for use in genome scans to detect QTL affecting various traits of interest in experimental
animal, human and agricultural pedigrees. Here, we propose a new approach to estimate IBD as continuous functions rather than
as discrete values. |
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