Phenolic derivatives from Garcinia multiflora Champion ex Bentham and their chemotaxonomic significance |
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| Affiliation: | 1. Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali, 671000, PR China;2. College of Pharmacy, Dali University, Dali, 671000, PR China;1. Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan;2. Graduate School of Bioscience and Bioindustry, Tokushima University, Tokushima 770-8513, Japan;3. Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 862-0082, Japan;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kumming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;1. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;3. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt |
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| Abstract: | A phytochemical investigation of the leaves and twigs of Garcinia multiflora Champion ex Bentham led to the isolation of eleven phenolic derivatives, including a new polycyclic polyprenylated acylphloroglucinol (PPAP, 1), five known PPAPs (2–6), three xanthones (7–9), a benzophenone (10), and a methyl phenyl acetate derivative (11). Their structures were established by extensive spectroscopic analysis, including HR-ESI-MS and NMR. Five compounds (1, 2, 4, 5, and 11) were first found in the genus Garcinia, of which compounds 1 and 11 were reported from the family Guttiferae for the first time. The chemotaxonomic significance of the isolated compounds was discussed. Furthermore, six PPAPs showed good cytotoxicities with IC50 values ranging from 1.79 to 9.40 μM. |
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| Keywords: | Guttiferae Phenolic compounds Chemotaxonomy Cytotoxicity |
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