Antitumor and hepatoprotective activity of natural and synthetic neo steroids |
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| Affiliation: | 1. Department of Chemistry and Physics, Halmos College of Natural Sciences and Oceanography, Nova Southeastern University, Fort Lauderdale, FL 33314, USA;2. Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA;1. Chemistry Department, Faculty of Science, Taibah University, Yanbu Al-Bahr, Saudi Arabia;2. Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt;3. Adana Alparslan Türkeş Science and Technology University, Department of Energy Systems Engineering, 01250 Adana, Turkey;1. Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt;2. Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt;3. Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, Egypt;1. Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt;2. TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany;3. Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt;2. Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Ghaziabad, Uttar Pradesh, India |
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| Abstract: | In this review, steroids with a tertiary butyl group, which are usually called neo steroids, are a small group of natural lipids isolated from higher plants, fungi, marine sponges, and yeast. In addition, steroids with a tertiary butyl group have been synthesized in some laboratories in Canada, USA, Europe, and Japan and their biological activity was studied. Some natural neo steroids demonstrate antitumor or hepatoprotective activities. In addition, synthetic neo steroids exhibit anticancer and neuroprotective properties. However, to confirm the above data, both practical and clinical experimental studies are necessary. Nevertheless, the results may be useful for pharmacologists, chemists, biochemists, and the pharmaceutical industry. |
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