Monoterpenoid glycoside derivatives from Melaleuca alternifolia |
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| Institution: | 1. Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany;2. Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany;3. Department of Neurology, Oslo University Hospital, Oslo, Norway;4. Department of Clinical Neuroscience, Institute of Psychiatry, King''s College London, London, UK;5. Center for Applied Genomics, Abramson Research Center, The Children''s Hospital of Philadelphia, Philadelphia, PA, USA;6. Division of Human Genetics, Abramson Research Center, The Children''s Hospital of Philadelphia, Philadelphia, PA, USA;7. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;8. Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;9. Max Planck Institute for Human Development, Berlin, Germany;10. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;11. Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany;12. Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy;13. Neuroscience Institute of Turin, Turin, Italy;14. Department of Neurology, Linköping University, Linköping, Sweden;15. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt, Germany;p. Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden;q. Department of Neurology, University of Ulm, Ulm, Germany;r. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway;s. School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;t. Neurosciences Division, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK;u. Department of Pharmacology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden;v. Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Oslo, Norway;w. Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany;x. Department of Clinical Pathology, Molecular Genetics Unit, Azienda Ospedaliera Città della Salute e della Scienza, Torino, Italy;y. Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany;z. Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK;11. Department of Neurology, Haukeland University Hospital, Bergen, Norway;12. Department of Clinical Medicine, University of Bergen, Bergen, Norway;13. Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy;14. Department of Pathophysiology and Tranplantation, “Dino Ferrari” Center, Università degli Studi di Milano, Milano, Italy;15. Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands;16. Interdisciplinary Metabolic Center, Lipids Clinic, Charité University Medicine, Berlin, Germany;17. German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany;18. Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany;19. Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK;110. West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust, London, UK;111. AXA Research Fund & UPMC Chair, Paris, France;112. Département de Neurologie, Sorbonne Universités, Université Pierre et Marie Curie, Institut de la Mémoire et de la Maladie d''Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpétrière, Paris, France;113. Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, CA, USA;1. Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1 Tsukisamu-Higashi, Toyohira-ku, Sapporo 062-8517, Japan;2. Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan;3. Biotechnology Research Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan |
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| Abstract: | The phytochemical investigation of leaves of Melaleuca alternifolia (Maiden & Betche) Cheel led to the isolation of a new monoterpenoid glycoside derivative melaleuoside (1), together with four known monoterpenoid glycoside derivatives (2–5). Structure elucidation of these compounds was performed based on NMR spectral data and MS. Compounds 2–5 were isolated from the genus of Melaleuca for the first time. Furthermore, we also discussed the chemotaxonomic significance of the isolates in this thesis. |
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| Keywords: | Monoterpenoid glycosides Chemotaxonomy |
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