A new ent-kaur-16-en-19-oic acid from the aerial parts of Inula bifrons |
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| Institution: | 1. Avignon University, Qualisud UMR95, F-84 000 Avignon, France;2. Qualisud, Univ Montpellier, CIRAD, Montpellier Sup''Agro, Université d''Avignon, Université de la Réunion, Montpellier, France;3. Aix Marseille Univ, Laboratory of Pharmacognosy and Ethnopharmacology, UMR-MD3, Faculty of Pharmacy, 27 Bd Jean Moulin, CS 30064, 13385, Marseille cedex 05, France;4. Luberon Natural Regional Park, 60 place Jean-Jaurès, BP 122, 84404 Apt, France;1. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran;2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;1. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, People’s Republic of China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China |
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| Abstract: | The phytochemical study of the chloroform extract of the aerial parts of Inula bifrons (L.) L. led to the isolation of one new ent-kaurane diterpenes acid along with twelve known compounds (two ent-kaurane diterpenoids, an eudesmane acid, five sesquiterpene lactones, three triterpenoids and β-sitosterol). All known compounds are found for the first time in I. bifrons. Their structures were elucidated by using spectral methods (NMR, HRESIMS and IR). The distribution of these compounds in the genus Inula and their chemotaxonomic significance is discussed. |
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| Keywords: | Sesquiterpenoids Triterpenoids Isolation |
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