Comparative proteomics and immunoproteomics of Helicobacter pylori related to different gastric pathologies |
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Authors: | Mini Roberta Bernardini Giulia Salzano Anna Maria Renzone Giovanni Scaloni Andrea Figura Natale Santucci Annalisa |
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Affiliation: | Dipartimento di Biologia Molecolare, Università degli Studi di Siena, via Fiorentina 1, 53100 Siena, Italy. |
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Abstract: | Helicobacter pylori is a Gram-negative bacterium which causes ulcer, atrophic gastritis, adenocarcinoma, or mucosa-associated lymphoid tissue lymphoma. A comparative proteomic and immunoproteomic analysis was chosen to identify the antigenic patterns of three different H. pylori strains. These strains were probed against single sera from H. pylori-positive patients affected by gastric adenocarcinoma or duodenal ulcer. We found a quite heterogeneous antigenic pattern, both from strain and sera points of view, thus underlying both a strain- and a host-specificity. The different antigenic repertoires introduced the importance of the strain to be used for immunoblotting as a diagnostic test. |
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