Priming in Oxytocin Cells and in Gonadotrophs |
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Authors: | Gareth Leng Celine Caquineau Mike Ludwig |
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Affiliation: | (1) Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK |
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Abstract: | At proestrous, the sensitivity of gonadotrophs to gonadotrophin-releasing hormone (GnRH) increases with repeated exposure to GnRH, a process known as self-priming. An apparently similar phenomenon can also occur in peptidergic neurons; activity-dependent oxytocin release from dendrites can be potentiated by oxytocin itself. In the brain, such priming actions have the potential to alter the strength of communication between neuronal populations for a very prolonged period. In the case of both oxytocin neurons and gonadotrophs, priming appears to involve an augmentation of a readily releasable pool of vesicles. Special issue article in honor of George Fink. |
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Keywords: | Hypothalamus Pituitary gland Dendritic release |
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