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Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair |
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| Authors: | Wei Zhang Jialin Chen Shufang Zhang Hong Wei Ouyang |
| Institution: | 1. 4th Department of Internal Medicine, Attikon University Hospital, 1 Rimini Str., Athens, 12462, Greece 2. Department of Medicine, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 8, 6525 GA, Nijmegen, The Netherlands 3. Inflammation and Immunity (N4i), Nijmegen Institute for Infection, 6525 GA, Nijmegen, The Netherlands |
| Abstract: | Cartilage repair tissue is usually accompanied by chondrocyte hypertrophy and osseous overgrowths, and a role for parathyroid hormone-related protein (PTHrP) in inhibiting chondrocytes from hypertrophic differentiation during the process of endochondral ossification has been demonstrated. However, application of PTHrP in cartilage repair has not been extensively considered. This review systemically summarizes for the first time the inhibitory function of PTHrP on chondrocyte hypertrophy in articular cartilage and during the process of endochondral ossification, as well as the process of mesenchymal stem cell chondrogenic differentiation. Based on the literature review, the strategy of using PTHrP for articular cartilage repair is suggested, which is instructive for clinical treatment of cartilage injuries as well as osteoarthritis. |
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