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Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin |
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| Authors: | Wen-Chi Wei Sheng-Yen Lin Yi-Jyun Chen Chih-Chun Wen Chiung-Yao Huang Arulselvan Palanisamy Ning-Sun Yang Jyh-Horng Sheu |
| Affiliation: | (1) Agricultural Biotechnology Research Center, Academia Sinica, Kragujevac, Taiwan;(2) Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan;(3) Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan;(4) Department of Life Science, National Central University, Taoyuan County, Taiwan;(5) Department of Life Science, National Taiwan University, Taipei, Taiwan;(6) Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung, Taiwan |
| Abstract: | BackgroundSkin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inflammatory and systemic immune responses against harmful stimuli. 12-O-tetradecanoylphorbol-13-acetate (TPA) can stimulate acute and chronic inflammation and tumor promotion in skin. TPA-induced dermatitis is thus a useful in vivo pharmacological platform for drug discovery. In this study, the inhibitory effect of briarane-type diterpenes (BrDs) from marine coral Briareum excavatum on TPA-induced dermatitis and dendritic cell (DC) function was explored. |
| Keywords: | Briarane-type diterpene TPA-induced mouse dermatitis Dendritic cells Vascular permeability Edema |
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