Foxe view of lens development and disease |
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Authors: | Medina-Martinez Olga Jamrich Milan |
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Affiliation: | Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. |
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Abstract: | The recent identification of a mutation in Foxe3 that causes congenital primary aphakia in humans marks an important milestone. Congenital primary aphakia is a rare developmental disease in which the lens does not form. Previously, Foxe3 had been shown to play a crucial role in vertebrate lens formation and this gene is one of the earliest integrators of several signaling pathways that cooperate to form a lens. In this review, we highlight recent advances that have led to a better understanding of the developmental processes and gene regulatory networks involved in lens development and disease. |
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