Cloning, nucleotide sequence and molecular evolution of a rabbit processed metallothionein MT-2 pseudogene |
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| Authors: | Y C Tam M Hassan A Chopra J P Thirion |
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| Affiliation: | Department of Microbiology, Faculty of Medicine, Centre Hospitalier Universitaire, Sherbrooke, Quebec, Canada. |
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| Abstract: | A rabbit metallothionein-2 pseudogene (MT-2 psi) has been isolated from a partial rabbit genomic library. Its unusual sequence shows evidence of complex rearrangements involving recombination and deletion events. There are no intervening sequences, 3' poly A tract or 5' regulatory DNA sequences. The pseudogene is flanked by two sets of direct repeats (CT)3 GT(CT)4 and CTGG(G)CTC. They are most probably the sites of insertion of MT-2 psi in the rabbit genome. In addition, a number of repetitive DNA sequences are observed flanking the MT-2 psi gene. These are features of a processed retrogene. |
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