BCG modulation of anaphylactic antibody response, airway inflammation and lung hyperreactivity in genetically selected mouse strains (Selection IV-A) |
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Authors: | Barros Myrthes Toledo Acencio Milena Marques Pagliarelli Garcia Maria Lúcia Bueno Macedo Soares Maria Fernanda Ibañez Olga M Martins Milton Arruda Ribeiro Orlando Garcia Kalil Jorge Perini Adenir |
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Affiliation: | Division of Clinical Immunology and Allergy, Heart Institute (InCor), Division of General Internal Medicine, Department of Medicine, University S?o Paulo, Av. Dr. Arnaldo, 455, Cerqueira César, 01246-903, S?o Paulo, Brazil. myrtb@uol.com.br |
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Abstract: | The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 anti-OVA, eosinophils in pulmonary tissue, inflammatory cells in bronchoalveolar lavage and the compliance and conductance of respiratory system were evaluated. H-IVA mice were found more susceptible than L-IVA, and BCG was able to inhibit simultaneously the production of IgE, the bronchopulmonary inflammation and bronchial hyperresponsiveness in these genetically selected mice. |
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