替考游动放线菌发酵生产替考拉宁的动力学模型

根据丝状菌的生长机理和替考拉宁的发酵动力学特征提出了一个简化的形态学结构模型，并用于描述替考拉宁的发酵过程．模型将菌丝分为三种类型：具有生长活性的菌丝(G)、具有代谢活性的菌丝(N)和失活的菌丝(D)．菌丝G可因失去生长活性而转化为菌丝N，菌丝N可因失去代谢活性而转化为菌丝D．菌丝G与菌丝生长有关，而菌丝N则与替考拉宁的合成有关．该模型能较好地描述替考拉宁发酵过程、

Kinetic Model of Teicoplanin Fermentation by ActionplanesT eichomyceticus

According to the growth mechanisms of filamentous microorganisms and the kinetic characters of teicoplanin formation, a simplified morphologically strutured model is proposed to describe the fermentation process of teicoplanin. The mycelia are divided into three components: active-growing mycelis(G), non-growth mycelia(N), and deactivated mycelia (D). Mycelia G can transfer into N mycelia after losing its growth activity, and mycelia N can become mycelia D after losing metabolic activity. Mycelia G is responsible for mycelial growth whereas mycelia N is responsible for teicoplanin production. The model simulations for mycelia growth and antibiotic formation are in good agreement with the experiment data for teicoplanin fermentation process.