Biphasic saturations of binding proteins can be the result of a competitive inhibition of substrate fixation. |
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| Authors: | C Gaudin B Marty M Ragot J C Sari J P Belaich |
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| Affiliation: | Laboratoire de Chimie Bactérienne, C.N.R.S., 13274 Marseille Cedex 2, France |
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| Abstract: | A mathematical model is proposed which explains some biphasic saturations of Binding Proteins by their substrates through an effect of a competitive inhibition. The inhibitor can be the substrate itself especially when the retention phenomenon is occuring. This model has been verified with two periplasmic Binding Proteins of Escherichia coli: the Glutamine Binding Protein and the Leucine-Isoleucine-Valine Binding Protein. A significant connection is found between experimental results and the hypothesis. |
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| Keywords: | To whom all correspondence should be addressed. |
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