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Integration of metabolic databases for the reconstruction of genome-scale metabolic networks |
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| Authors: | Karin Radrich Yoshimasa Tsuruoka Paul Dobson Albert Gevorgyan Neil Swainston Gino Baart Jean-Marc Schwartz |
| Affiliation: | 1.Faculty of Life Sciences, University of Manchester,Manchester,UK;2.Helmholtz-Zentrum München, Technische Universit?t München,München,Germany;3.National Centre for Text Mining, University of Manchester,Manchester,UK;4.Japan Advanced Institute of Science and Technology,Nomi, Ishikawa,Japan;5.School of Chemistry, University of Manchester,Manchester,UK;6.Cell Systems Modelling Group, School of Life Sciences, Oxford Brookes University,Oxford,UK;7.Faculty of Health and Medical Sciences, University of Surrey,Guildford, Surrey,UK;8.Manchester Centre for Integrative Systems Biology, University of Manchester,Manchester,UK;9.VIB Department of Plant Systems Biology/Department of Biology,Ghent University,Gent,Belgium |
| Abstract: | BackgroundGenome-scale metabolic reconstructions have been recognised as a valuable tool for a variety of applications ranging from metabolic engineering to evolutionary studies. However, the reconstruction of such networks remains an arduous process requiring a high level of human intervention. This process is further complicated by occurrences of missing or conflicting information and the absence of common annotation standards between different data sources. |
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