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The Role of Excitatory Amino Acid Transporters in Cerebral Ischemia |
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| Authors: | Xiao-dong Chao Fei Fei Zhou Fei |
| Institution: | (1) Department of Neurosurgery, Xi Jing Hospital, Fourth Military Medical University, Xi’an, 710032, China;(2) Department of Cell Biology/Cell Engineering Research Centre, Cancer Biology of State Key Laboratory and State Key Discipline of Cell Biology, Fourth Military Medical University, Xi’an, 710032, China |
| Abstract: | Glutamate is an excitatory neurotransmitter that plays a major role in the pathogenesis of ischemia brain injury. The regulation of glutamate neurotransmission is carried out by excitatory amino acid transporters (EAATs) that act through reuptake of glutamate into cells. EAATs may also release glutamate into the extracellular space in a calcium-independent manner during ischemia and dysfunction of EAATs is specifically implicated in the pathology of cerebral ischemia. Recent studies show that up-regulation of EAAT2 provides neuroprotection during ischemic insult. This review summarizes current knowledge regarding the role of EAATs in cerebral ischemia. |
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