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GO Explorer: A gene-ontology tool to aid in the interpretation of shotgun proteomics data
Authors:Paulo C Carvalho  Juliana SG Fischer  Emily I Chen  Gilberto B Domont  Maria GC Carvalho  Wim M Degrave  John R Yates III  Valmir C Barbosa
Institution:(1) Systems Engineering and Computer Science Program, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;(2) Department of Chemical Physiology, The Scripps Research Institute, La Jolla, USA;(3) Chemistry Institute, Federal University of Rio de Janeiro, and Rio de Janeiro Proteomics Network, Rio de Janeiro, Brazil;(4) Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;(5) Oswaldo Cruz Institute, Laboratory for Functional Genomics and Bioinformatics, Rio de Janeiro, Brazil;(6) Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA
Abstract:

Background  

Spectral counting is a shotgun proteomics approach comprising the identification and relative quantitation of thousands of proteins in complex mixtures. However, this strategy generates bewildering amounts of data whose biological interpretation is a challenge.
Keywords:
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