Computing phenomenologic Adair-Klotz constants from microscopic MWC parameters |
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Authors: | Melanie I Stefan Stuart J Edelstein Nicolas Le Novère |
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Institution: | (1) Computational Neurobiology Group, EMBL-EBI, Wellcome-Trust Genome Campus, Hinxton, CB10 1SD, UK |
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Abstract: | Background Modellers using the MWC allosteric framework have often found it difficult to validate their models. Indeed many experiments
are not conducted with the notion of alternative conformations in mind and therefore do not (or cannot) measure relevant microscopic
constant and parameters. Instead, experimentalists widely use the Adair-Klotz approach in order to describe their experimental
data. |
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Keywords: | |
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